The Future of Dengue Vaccination: Research and Development

  Dengue is a mosquito-borne viral disease that is particularly common in tropical and subtropical areas of the world. This disease can lead to serious complications and even death. In this article, we will look at the direction of research on Dengue vaccination and summarize what the situation is today.

   Current Dengue Vaccines


  The first and only currently approved Dengue vaccine is Dengvaxia, which has been available since 2015. This vaccine is effective against all four serotypes of Dengue virus.

  Dengvaxia is only recommended for people between the ages of 9 and 45 who have already been exposed to the Dengue virus. This finding follows the observation that in people who have not been previously exposed to the Dengue virus, the vaccine may increase the risk of severe disease if they are later infected.


   New vaccines in trials


  New Dengue vaccines that will also be safe and effective for people who have not been previously exposed to Dengue viruses are being studied to achieve broader protection.

  For example, Takeda's TAK-003 vaccine is currently in Phase III clinical trials. Preliminary results look promising, with the vaccine showing efficacy against all four serotypes of the virus, regardless of previous exposure to Dengue virus.

  Other vaccines under investigation use different platforms, such as DNA-based vaccines, mRNA-based vaccines, subunit vaccines and others. These vaccines are in various phases of clinical trials.

   The Future of Dengue Vaccines


  Given the complexity of Dengue - four different serotypes of the virus that can cause infection and even harm plasma that has not previously acquired immunity - creating an effective and safe vaccine is a huge challenge.

  However, advances in vaccine technology, knowledge of the Dengue virus and understanding of human immunity offer hope that better vaccines are on the horizon.

  Dengue vaccines are a key tool in the fight against this potentially deadly disease. Continued research and development can help create an effective and safe vaccine that provides protection on a global scale.

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